2010 |
Rizza, Stacey A; Cummins, Nathan W; Rider, David N; Saeed, Sahar; Klein, Marina B; Badley, Andrew D AIDS, 24 (17), pp. 2639-2644, 2010. Abstract | Links | BibTeX | Tags: Apoptosis-inducing ligand receptor 1, HIV-HCV co-infection, Polymorphism, Tumor necrosis @article{Rizza2010, title = {Polymorphism in tumor necrosis factor-related apoptosis-inducing ligand receptor 1 is associated with poor viral response to interferon-based Hepatitis C virus therapy in HIV/Hepatitis C virus-coinfected individuals}, author = {Stacey A. Rizza and Nathan W. Cummins and David N. Rider and Sahar Saeed and Marina B. Klein and Andrew D. Badley}, url = {https://www.ncbi.nlm.nih.gov/pubmed/20802294}, doi = {10.1097/QAD.0b013e32833eacfd}, year = {2010}, date = {2010-11-15}, journal = {AIDS}, volume = {24}, number = {17}, pages = {2639-2644}, abstract = {OBJECTIVE(S): HIV/hepatitis C virus (HCV) coinfection causes accelerated liver disease compared to HCV monoinfection, and only 30-60% of HIV/HCV-coinfected individuals respond to HCV therapy with pegylated interferon and ribavirin. There are currently no biomarkers that predict treatment response in these coinfected patients. DESIGN: We investigated whether there is an association between HCV treatment response and SNPs of apoptosis-related genes during HIV/HCV coinfection. METHOD: Genomic DNA from 53 HIV/HCV-coinfected individuals was analyzed for 82 SNPs of 10 apoptosis-related genes. RESULTS: We found that the presence of the rs4242392 SNP in tumor necrosis factor receptor superfamily, member 10a (TNFRSF10A), which encodes for tumor necrosis factor-related apoptosis-inducing ligand receptor 1, predicts poor outcome to HCV therapy, in HIV/HCV-co-infected patients [odds ratio 5.91 (95% confidence interval 1.63-21.38, P = 0.007)]. CONCLUSION: The rs4242392 SNP of the tumor necrosis factor-related apoptosis-inducing ligand receptor 1 gene predicted poor interferon-based HCV treatment response in HIV/HCV-coinfected patients.}, keywords = {Apoptosis-inducing ligand receptor 1, HIV-HCV co-infection, Polymorphism, Tumor necrosis}, pubstate = {published}, tppubtype = {article} } OBJECTIVE(S): HIV/hepatitis C virus (HCV) coinfection causes accelerated liver disease compared to HCV monoinfection, and only 30-60% of HIV/HCV-coinfected individuals respond to HCV therapy with pegylated interferon and ribavirin. There are currently no biomarkers that predict treatment response in these coinfected patients. DESIGN: We investigated whether there is an association between HCV treatment response and SNPs of apoptosis-related genes during HIV/HCV coinfection. METHOD: Genomic DNA from 53 HIV/HCV-coinfected individuals was analyzed for 82 SNPs of 10 apoptosis-related genes. RESULTS: We found that the presence of the rs4242392 SNP in tumor necrosis factor receptor superfamily, member 10a (TNFRSF10A), which encodes for tumor necrosis factor-related apoptosis-inducing ligand receptor 1, predicts poor outcome to HCV therapy, in HIV/HCV-co-infected patients [odds ratio 5.91 (95% confidence interval 1.63-21.38, P = 0.007)]. CONCLUSION: The rs4242392 SNP of the tumor necrosis factor-related apoptosis-inducing ligand receptor 1 gene predicted poor interferon-based HCV treatment response in HIV/HCV-coinfected patients. |
Research Papers
2010 |
AIDS, 24 (17), pp. 2639-2644, 2010. |